What is Ivermectin?
Ivermectin is “the wonder drug” from Japan, discovered in the late 1970s. Derived from a single microorganism found in Japanese soil, ivermectin was originally introduced as a veterinary drug and used widely in agricultural applications. It was quickly adopted to combat river blindness and other parasitic infections and distributed to billions of people around the world, effectively eradicating these scourges. An anti-parasitic, ivermectin is used to treat onchocerciasis, head lice, scabies, and many other types of parasite infections. It is also used externally to treat eczema.
In the same way that penicillin was a cure-all for bacterial infection, ivermectin is a panacea for viruses and parasites. Ivermectin is highly effective and broad-spectrum, safe, well tolerated and can be easily administered.
Why would an anti-parasitic work to eradicate coronavirus?
The answer lies in this virus’ life cycle, and a relatively unknown effect of ivermectin.
Most viruses enter your cells, and simply begin replicating. They take their course, the body learns how to fight them, it fights them off, and you recover. That is not the case with COVID. Instead, coronavirus protein enters the cell nucleus via the Importin α/β proteins, proteins that interact with surface of your cell nucleus that move things forth. This gives the virus two advantages. One is that it can evade the cytosolic immune system – that is, it hides – by disabling the cell’s antiviral weapons factory, ISGs. The second is that MHC-II, a protein your cells send to the surface so your immune system can identify an infection and fight it with antibodies, is disabled. Together, these factors enable the virus to hide undetected.
Ivermectin interrupts this cloaking action by binding and blocking association of the importin proteins. This has two effects. Firstly, freshly reproduced protein cannot make its way back into the nucleus. With a little time, this causes the viral protein to be extricated from the nucleus – it simply burns out and is degraded, without being replenished. This subsequently leaves the viral RNA vulnerable to immune attack in the cytosol.
This takes some time, and unlike in its anti-parasite applications, ivermectin’s antiviral effect does not last long at all within the cell. As the ivermectin must wait out the degradation of all nucleic protein, repeated doses are usually necessary, unless a person has a very early infection and it has not spread significantly. At the end of the day, with only the application of ivermectin, the progression of disease is as follows:
For a short time, the virus continues replicating as normal. Cytosolic immunity is gradually activated as the drug permeates tissue and nucleic protein degrades, and cytosolic vRNA begins to be destroyed by interferon-based cell immunity. Free virions continue to infect cells. Their protein is unable to enter the cell nucleus, and so while they may still replicate for a short period before they are destroyed, the virus does not survive much longer. Over time, the viral load lessens as infected cells begin to clear their infections. Eventually, no free virions remain in the blood, no vRNA remains in the cytosol nor protein in the nucleus, and the virus is eradicated from the body.
The only concern at this point is the free virions permeating the air in your living room. Care must be taken to disinfect everything in the environment that has been tainted by the virus. Exactly how long coronavirus hangs in the air and lives on surfaces is still to be determined, but we assume the virus can linger in the air for several hours and on surfaces for up to a month. If available, UVC lights can be used to sterilize entire rooms. The importance of disinfecting completely cannot be understated.
Is that it? Really?
Since coronavirus may also infect the gut bacteria, it would probably be wise for doctors to pair ivermectin with an antibiotic to kill it in the gut bacteria, to preclude the possibility of patients being reinfected. The science on this is still out, but it may be useful.
Zinc can also be taken to accelerate the degradation of the virion. Quercetin, EGCG, azithromycin, doxycycline and ivermectin – these all do the same thing – they will let zinc into the cell and hasten the process.
Is Ivermectin prophylactic?
Ivermectin stays in some tissues and fights parasites for months. In antiviral application it is very short lived – part of the molecule temporarily blocks the nucleic importin protein while a therapeutic concentration is present in the bloodstream. It MAY be prophylactic for a short time. One would not want to dose it regularly, however. It manually activates cytosolic immunity, producing interferons, which the cell uses to clean up vRNA. Interferons are immune signals you do not want floating around permanently. Prolonged use may cause autoimmune issues.*
*Note: Trials have since determined that no such adverse events related to autoimmunity – or significant adverse events at all – have been observed with repeated daily dosing over the course of a month. As noted above, this article was written quite some time ago, and the science has advanced significantly since that time. The original text is preserved for historical record. Currently recognized pre-exposure prophylaxis protocols vary between 1-2 week dosing intervals, and post-exposure prophylactic protocols generally call for a dose on day 1 and on day 3.
Why isn’t Ivermectin being widely used to treat COVID?
This PDF outlines how a hospital in Peru is using Ivermectin right now with 100% success in treating COVID patients. Ivermectin has also been adopted as the first line of defense in the Dominican Republic. It is also being used in Bangladesh, Bolivia, and Broward County, Florida to treat COVID patients right now. If we could get Ivermectin to the attention of the right people, we could end the lockdowns and put an end to this crisis.
Hospitals are not going to just start using this by themselves. The system is broken by corruption, and they all want to profit from Remdesivir, which barely has any effect. Your community needs your help. Fax, call and email your government representatives, governors, hospitals, doctors and local news outlets, and make sure they cannot ignore this. You can use this online fax service – after free signup, they give you 500 free pages. They do not charge immediately. The document is 9 pages long. https://hellofax.com/
SPREAD THE WORD.
The old text is below for posterity only. Please see above for the most reliable, clear-cut, detailed information you will find.
“COVID-19 DE LARGA DURACIÓN: TRATAMIENTO CON IVERMECTINA DE PACIENTES CON SINTOMAS PERSISTENTES” https://www.researchgate.net/publication/342735011_COVID-19_DE_LARGA_DURACION_TRATAMIENTO_CON_IVERMECTINA_DE_PACIENTES_CON_SINTOMAS_PERSISTENTES
“A comparative observational study on Ivermectin- Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients” https://www.researchgate.net/publication/342159343_A_comparative_observational_study_on_Ivermectin-_Doxycycline_and_Hydroxychloroquine-Azithromycin_therapy_on_COVID19_patients
ICON (Ivermectin in COVID Nineteen) study: Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with COVID19 https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2
Usefulness of Ivermectin in COVID-19 Illness: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524
Antivirus effectiveness of ivermectin on dengue virus type 2 in Aedes albopictus: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277121/
The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways: https://www.ncbi.nlm.nih.gov/pubmed/26351913
Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo: https://www.ncbi.nlm.nih.gov/pubmed/30266338
Breakthrough Drug: Ivermectin Shows ‘Astounding’ Results Against Coronavirus “There’s a common denominator here,” said Hibberd. “This drug is salvaging people from their death bed.” https://www.newsmax.com/us/ivermectin-drug-virus/2020/05/22/id/968688/
Bolivian city gives out free doses of de-worming drug in bid to combat coronavirus “Authorities will go house-to-house to pass out some 350,000 doses of the drug to residents in the region of Beni, where Trinidad is the capital.” https://www.reuters.com/article/us-health-coronavirus-bolivia-drug/bolivian-city-gives-out-free-doses-of-de-worming-drug-in-bid-to-combat-coronavirus-idUSKBN22V2U7
A group of doctors in Bangladesh applied a drug, used mainly for dermatological conditions such as scabies, on COVID-19 patients: ivermectin: https://bdnews24.com/health/2020/05/16/does-ivermectin-work-against-covid-19-some-say-yes
Found effective drug combination to cure Covid-19 patients: Bangladeshi doctors https://www.hindustantimes.com/india-news/found-effective-drug-combination-to-cure-covid-19-patients-bangladeshi-doctors/story-K8z0YQD43b2KbptPQAwLdO.html
Local Doctor Tries New Coronavirus Drug Treatment: https://www.nbcmiami.com/news/local/local-doctor-tries-new-coronavirus-drug-treatment/2219465/
Dr. Jhonny Tavarez Capellan obtains a medical discovery that could be a panacea for the COVID-19 pandemic: https://revistamedica.do/dr-jhonny-tavarez-capellan-obtiene-un-descubrimiento-medico-que-pudiera-ser-una-panacea-para-la-pandemia-del-covid-19/
Broward County Doctor Using Ivermectin Off-Label Combo on COVID-19 Patients—It is Working & Secures County Health Protocol Approval: https://www.trialsitenews.com/broward-county-doctor-using-ivermectin-off-label-combo-on-covid-19-patients-it-is-working-secures-county-health-protocol-approval/
This study purports to demonstrate Ivermectin’s capacity to kill the virus in vitro. However, they do so by using an extremely high concentration of the drug, which is clearly not achievable in vivo. This has misled doctors and scientists about its potential efficacy. Such high concentrations are not required. Lower concentrations were also not tested.
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro: https://www.sciencedirect.com/science/article/pii/S0166354220302011
This study purports to demonstrate that a single dose of ivermectin cannot reach the IC50 demanded by the “pharmacokinetic model” utilized by these researchers, based on the above study. There is no information given about their model, and the study relies on the flawed work of the previous study. Ivermectin in standard doses has been proven in vivo to eradicate both SARS-CoV-2, Dengue Fever, and various other viruses. They are truthful about one aspect, namely that a single dose is insufficient. They have also disclosed funding from the Bill and Melinda Gates Foundation.
The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID-19: https://www.medrxiv.org/content/10.1101/2020.04.21.20073262v1
WARNING. THIS PROTOCOL IS STILL UNDER DEVELOPMENT. IVERMECTIN IS CONTRAINDICATED IN CHILDREN UNDER FIVE, PREGNANT WOMEN, THOSE WITH LIVER OR KIDNEY DISEASE, AND IS DANGEROUS OR DEADLY IN OVERDOSE. USE WITH MEDICAL SUPERVISION AND ADVICE.
Ivermectin is a drug typically used in the treatment of malaria and other parasitic diseases. However, it is also a macrolide antibiotic, and a potent antiviral, proven in vivo to eradicate Dengue Fever within 12 hours, and proven in vivo against SARS-CoV-2 within 48 hours. It would not be a stretch to call ivermectin a panacea capable of treating a very broad range of diseases that plague the world today.
With that said, you will need:
– UV lights – 185nm or 253nm, depending on your space
– Amoxicillin clavulanate, or another safe antibiotic capable of killing gram-negative bacteria.
– Ivermectin, in any edible preparation
– Quercetin 500mg
– Zinc 30-50mg
– Liposomal C, or another strong antiviral of your choice.
Follow these steps:
1. Begin your course of amoxicillin clavulanate and C. This is to eradicate all gut microbiota from your body, as they are susceptible to infection, and to bring your viral load to or near zero, respectively.
2. 48 hours later, take a single oral dose of Ivermectin, 150 ***micro***grams per kilogram of body weight (NOT milligrams.) Continue your course of antibiotics to completion.
3. 8 hours after dosing Ivermectin, take 500mg Quercetin, and 50mg Zinc. Quercetin acts as a zinc ionophore, and allows high concentrations of zinc to enter your cells, which inhibits viral replication. This synergizes with Ivermectin’s virucidal action.
4. Thoroughly sterilize your surroundings with UV light and/or ozone. Both UV light and ozone are very dangerous to eyes, skin and lungs; do not expose yourself to either of them. Begin this very shortly after taking your Zinc and Quercetin. Be mindful of potentially contaminated air vents or sewage piping that may be shared with other residences, and sterilize accordingly.
5. Repeat Zinc and Quercetin per 6 hours.
6. 24 hours after first dose of Ivermectin, repeat another 150mcg/kg dose.*
7. Within 48 hours of your first dose of Ivermectin, you will be cured. STAY INSIDE!
*This is presently under development. The most important aspects of Ivermectin treatment are a) sufficiently long exposure (known as Area Under the Curve, or AUC) to eradicate all viral RNA, and b) avoiding overdose, which can have dangerous or deadly side effects. It is also under consideration that the second dose be split into two doses, of 75mcg/kg, at the 18 and 36 hour mark. This may be safer for those who are above 275 lbs. Elimination of the virus has been observed both by doctors who have used a single dose, and by doctors who have repeated another dose after 24 hours.
You may want to ask your doctor, and consider any possible contraindications that may not be listed here to the various medications in protocol, before commencing treatment.
This is the procedure I am using. This differs from the process described in the hospital procedure document above, in several regards. Seek professional medical advice about, and medical supervision during, using this protocol. Side effects or contraindications may be dangerous or deadly to yourself or your unborn baby depending on your circumstances.
This also differs from the incomplete protocol described in the old text. That procedure was developed before professional medical advice about the use of ivermectin became available (PDF above.) This has been revised to reflect newly available information.
At hour zero:
1. Ivermectin, oral. If body weight is below 80 kg (176 lbs), take 12mg. If above, take 18mg. Ivermectin inhibits the nucleic importin protein, and activates cytosolic cellular immunity. These interrupt the life cycle of COVID, causing it to burn out and cease reproducing, and allows the cell to clean up the remaining viral RNA, respectively.
2. Amoxicillin clavulanate, oral, or another antibiotic capable of killing gram-negative bacteria. This is to eradicate all gut microbiota, as there is strong evidence that COVID may also infect those, and serve as a vector for reinfection.
3. Liposomal ascorbic acid, oral, 55mg per kg of body weight. For an 80kg person, this is 4.4 grams.
Repeat liposomal ascorbic acid per 3 hours, and amoxicillin clavulanate per 12 hours (or per directions), until completion.
At hour six:
4. Zinc 30-50mg, oral, any preparation. Zinc inhibits cytosolic viral reproduction, slowing or stopping the virus producing proteins in your cells, and preventing it from competing with ivermectin to disable cytosolic immunity.
5. Quercetin, 500mg, oral. Quercetin is a zinc ionophore, and allows higher concentrations of zinc to enter your cells. This enhances the inhibitory effect of zinc.
Repeat zinc and quercetin per 6 hours until completion.
At hour sixteen:
6. Sterilize your home with UV-C light. 185 nm will produce a lot of ozone; 253.4 nm will only produce a little. UV-C is dangerous to eyes and skin with even brief exposure; do not be at home during this time. Wait 4 hours for the lights to sterilize, and another 4 hours for residual ozone to dissipate. Ozone is a highly reactive oxygen species that will damage skin, lungs, eyes, and all other tissues. Do not expose yourself to it. The virus lives on surfaces and in air for a very long time; days, perhaps up to a month on some surfaces, so UVC sterilization, or a similar approach such as fogging, is what you will need. Normal cleaning and scrubbing will not eradicate the virus.
At hour 24:
7. Repeat ivermectin as per above.
At hour 48:
8. Repeat ivermectin as per above.
9. Sterilizing again is a good idea. With ivermectin and liposomal ascorbic acid in your system, you are temporarily immune to the virus. Use this time to clean nooks and crannies that you expect the UVC light did not reach.
At hour 72:
10. You are cured! Do not go outside.
11. Do not take a vaccine. There is a good reason we have never had a vaccine for the common cold coronavirus – coronavirus vaccines cause antibody dependent enhancement, which is extremely lethal. The scientists running the government know this, and they are pushing vaccines out anyway. This is not an indictment of all vaccines; many, most even, are good, necessary, and do their job well. Coronavirus vaccines have always been deadly.
DO NOT TAKE A VACCINE.
What measurement is to be taken, how many times in a day and for how long?
Ivermectin, oral. If body weight is below 80 kg (176 lbs), take 12mg. If above, take 18mg. Ivermectin inhibits the nucleic importin protein, and activates cytosolic cellular immunity. 2-4 doses depending on severity, 24h apart.
Pharmacokinetics: How does the body handle this drug? How is it broken down? How is it cleared from the body?
It is metabolized by the liver by CYP3A4 and excreted in feces.
Route of Administration: How is it to be administered?
Precautions: What are the precautions to be taken while using this drug? Can it be used with alcohol? Tobacco?
Avoid alcohol. Contraindicated in children under 5 and pregnant women.
Can it be used while operating machinery?
Yes, machinery is fine.
Pharmacodynamics: How does this drug work?
Ivermectin inhibits the nucleic importin protein, and activates cytosolic cellular immunity. These interrupt the life cycle of COVID, causing it to burn out and cease reproducing, and allows the cell to clean up the remaining viral RNA, respectively.
Side Effects: What are the undesirable effects someone can experience from using it.
May cause mild rash and headache. In overdose or in combination with P450 inhibitor can cause extensive brain damage. Wide therapeutic window, safe up to 13x required therapeutic dose.
Contraindications: In which co-morbodities should this drug be avoided?
Pregnancy: Will induce abortion.
Blood-brain barrier inflammation contraindicates use.
Interactions: How does this drug interact with other drug the patient might be taking?
P450 inhibitors can cause brain damage in combination with Ivermectin.
Overdose: What exactly can be done if there is accidental overdosing of the drugs?
Wide therapeutic margin; studies have proven safe up to 2000mcg/kg, but only 150mcg/kg repeated 1-3 times is necessary.